Chen Lab Baylor College of Medicine

Decode our own genome

With over 30 million variants in the human genome, which ones are important? Through the lens of human variation and diseases, we focus on advancing our ability to identify, assess, and predict variants with functional consequences using an interdisciplinary approach.

Our lab uses innovative genetics and genomics, single cell omics, computational, and imaging tools to understand the connection between genetic variants and human diseases, using the visual system as the model.

Our own genomes carry the story of evolution, written in DNA, the language of molecular genetics, and the narrative is unmistakable.


Our Research

By using patient data, mice model, and retinal organoids, our research aims to identify, assess, and predict genetic variations which can lead to Mendelian and complex visual disorders.

See what we’ve published

Our Resources

We believe that anyone around the world should be able to use and extend our work. We push to make software, tools, datasets, etc. that are freely available.

Browse our tools and datasets

Our Team

We are a team of enthusiastic researchers and we strive to build an inclusive environment for research, and recognize the value of diversity in the process of discovery.

Meet our team